Tracking Personalised Gut Microbiome and Glycemia Responses to Asian Diets - A Scalable Community Based Approach

Yong, G., Tay, C., Ha, S., Tachibana, J., See, E., Tjahyo, A. S., & Lim, J. (2025). Tracking personalised gut microbiome and glycemia responses to Asian diets: A scalable community-based approach [Poster presentation]. Precision Public Health Asia Conference 2025

Diet and the gut microbiome play key complementary roles in the prevention and management of many modern diseases. Diet-microbiome interactions and their effects on metabolic health remain poorly understood in Asians. To address this knowledge gap, we track 200 community-based, clinically healthy subjects from the general population over a 9-day, primarily remote full-feeding dietary intervention to 1) Identify factors that influence postprandial glycaemic and lipemic responses to nutritionally varied and common Asian foods, and 2) Quantify the acute effects of standard versus healthier Singaporean diets on gut microbiome and metabolic health outcomes. Participants were tracked for sleep, physical activity and postprandial blood glucose and lipids. Stool, saliva, blood, urine and skin tapes were collected throughout the study and will be analysed for metagenomic and/or metabolomic profiles. Preliminary data demonstrated inter-individual baseline variation in BMI, sleep quality, stress and body constitution among clinically healthy subjects. Ongoing efforts are focused on identifying microbiome, diet, metabolic and clinical features that explain such baseline and post-prandial variation, which in turn will help develop actionable precision nutrition solutions tailored to Asians.