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Review article: the gut microbiome in inflammatory bowel disease—avenues for microbial management

Admin Clinical Papers May 29, 2017

Disease remission and relapse are associated with microbial changes in both mucosal and luminal samples. In particular, a loss of species richness in Crohn’s disease has been widely observed. Existing therapeutic approaches broadly fall into 3 categories, namely: accession, reduction or indirect modulation of the microbiome. In terms of microbial…

The gut microbiome in health and in disease

Admin Clinical Papers January 1, 2016

There is a fast growing collection of data describing the structure and functional capacity of themicrobiome in a variety of conditions available to the research community for consideration and furtherexploration. Ongoing efforts to further characterize the functions of the microbiome and the mechanismsunderlying host–microbe interactions will provide a better understanding…

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Admin Clinical Papers July 16, 2008

The chronic inflammation characteristic of UC and CD is suggestive of an inability on the part of patients to control basal level inflammation within gut-associated lymphoid tissues. In this study, we have used culture-independent phylogenetic analysis to characterize the GI microbiotas of IBD patients and non-IBD controls. Sequence analysis indicates…

Microbial influences in inflammatory bowel diseases

Admin Clinical Papers February 1, 2008

Clinical, experimental, and therapeutic studies suggest an important role for microbial agents in Crohn’s disease and pouchitis pathogenesis. Bar-nich and Darfeuille-Michaud described adherent/invasive E. coli (AIEC) that persist within epithelial cells and macrophages and selectively colonize the ileum of Crohn’s disease patients.