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The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression

Admin Clinical Papers March 22, 2018

We found that the cancerous pancreas harbors a markedly more abundant microbiome compared to normal pancreas in both mice and humans, while select bacteria are differentially increased in the tumorous pancreas compared to gut. Ablation of the microbiome protects against pre-invasive and invasive PDA, whereas transfer of bacteria from PDA-bearing…

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Admin Clinical Papers September 15, 2017

Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2′,2′-difluorodeoxycytidine) into its inactive form, 2′,2′-difluorodeoxyuridine. Metabolism was dependent on the expression of a long isoform of the bacterial enzyme cytidine deaminase (CDDL),…