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Clinical Papers

Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: a meta‑analysis of randomized clinical trials

Admin Clinical Papers July 16, 2020

Probiotics have been reported to have a positive impact on the metabolic control of patients with type 2 diabetes. We aimed to systematically evaluate the effects of probiotics on cardiometabolic parameters in type 2 diabetes based on randomized controlled studies. MEDLINE, Embase, and CENTRAL databases were reviewed to search for…

Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance

Admin Clinical Papers July 10, 2020

Background: Interleukin-2 (IL-2) serves as a pioneer of immunotherapeutic agent in cancer treatment. However, there is a considerable proportion of patients who cannot benefit from this therapy due to the limited clinical responses and dose-limiting toxicities. Mounting evidence indicates that commensal microbiota shapes the outcome of cancer immunotherapies. In this…

Microbiome signatures of nutrients, foods and dietary patterns: Potential for personalized nutrition from The PREDICT 1 Study

Admin Clinical Papers May 29, 2020

The PREDICT 1 study (NCT03479866) enrolled 1,102 healthy US and UK adults to examine the genetic, metabolic, microbial, and meal composition/context contributions to metabolic responses to food. They observed strong associations between overall microbial structure, as well as feature-level associations with nutrients, foods, food groups, and established dietary indices. Strongest…

Gut microbiota and metabolic syndrome

Admin Clinical Papers April 5, 2020

Metabolic syndrome (MetS) describes a set of risk factors that can eventually lead to the occurrence of cardiovascular andcerebrovascular disease. A detailed understanding of the MetS mechanism will be helpful in developing effective preventionstrategies and appropriate intervention tools.

Cheese and healthy diet: Associations with incident cardio-metabolic diseases and all-cause mortality in the general population

Admin Clinical Papers December 17, 2019

Many countries have established Food-Based Dietary Guidelines (FBDG). For some foods, such as cheese, there is no consensus on whether or not to include them in these guidelines. Cheese may, however, be an excellent source of vitamin K2, which is a macronutrient with demonstrated positive results on cardiovascular-related outcomes.

Persistent gut microbial dysbiosis in children with Acute Lymphoblastic Leukemia (ALL) during chemotherapy

Admin Clinical Papers November 21, 2019

We observe that the microbiota diversity and richness of the ALL group is significantly lower than that of the control group at diagnosis and during chemotherapy. The microbiota diversity is even lower in antibiotics-exposed ALL patients. Although the gut microbial diversity tends to stabilize after 1-year post-chemotherapy, their abundances were…