Gut Check

Month: October 2020

Ozone as adjuvant support in the treatment of COVID‐19: A preliminary report of probiozovid trial

The evaluation of new therapeutic resources against coronavirus disease 2019(COVID‐19) represents a priority in clinical research considering the minimal optionscurrently available. To evaluate the adjuvant use of systemic oxygen‐ozone admin-istration in the early control of disease progression in patients with COVID‐19pneumonia. PROBIOZOVID is an ongoing, interventional, randomized, prospective,and double‐arm trial enrolling patient with COVID‐19 pneumonia. From a total of 85patients screened, 28 were recruited. Patients were randomly divided into ozone‐autohemotherapy group (14) and control group (14). The procedure consisted in adaily double‐treatment with systemic Oxygen–ozone administration for 7 days. Allpatients were treated with ad interim best available therapy. The primary outcomewas delta in the number of patients requiring orotracheal‐intubation despite treat-ment. Secondary outcome was the difference of mortality between the two groups.Moreover, hematological parameters were compared before and after treatment. Nodifferences in the characteristics between groups were observed at baseline. As apreliminary report we have observed that one patient for each group needed in-tubation and was transferred to ITU. No deaths were observed at 7–14 days of followup. Thirty‐day mortality was 8.3% for ozone group and 10% for controls. Ozonetherapy did not significantly influence inflammation markers, hematology profile, andlymphocyte subpopulations of patients treated. Ozone therapy had an impact onthe need for the ventilatory support, although did not reach statistical significance.Finally, no adverse events related to the use of ozone‐autohemotherapy werereported. Preliminary results, although not showing statistically significant benefits ofozone on COVID‐19, did not report any toxicity.

The effects of probiotics, prebiotics and synbiotics on the reduction of IBD complications, a periodic review during 2009–2020

Aims: To perform a systematic review on randomized controlled trials to examine the efficacy of probiotics, prebiotics and synbiotics in the treatment of IBD. Methods and Results: PubMed, Web of science, Scopus and Google Scholar were systematically searched from January 2009 to January 2020 using the following keywords: ‘Inflammatory Bowel Disease’, ‘Probiotics’ and ‘Clinical trial’. The statistical analysis was performed using SPSS software version 24.0. A total of 1832 articles were found during the initial search and 21 clinical trials were eligible. Studies comparing the effects of probiotics and placebo among patients with active ulcerative colitis (UC) showed a significant difference in clinical outcomes. Moreover, probiotics improved the overall induction of remission rates among patients with Crohn’s disease (CD). Probiotics significantly decreased the IL-1b, TNF-a and IL-8 levels. Also, the need for systemic steroids, hospitalization, surgery, as well as histological score and disease activity index significantly decreased in patients who used probiotic or pro-/synbiotics. Conclusions: The use of probiotics, as food supplements, can induce antiinflammatory reactions, balance the intestinal homeostasis and induce remission in IBD. The efficacy of probiotics on remission induction is more reported in UC rather than CD. Larger well-designed clinical trials are needed to further determine whether probiotics are of clear benefits for remission in IBD.

Seaweed: The Ocean’s Forgotten Gem

Share on facebook Facebook Share on google Google+ Share on twitter Twitter Share on linkedin LinkedIn We’ve all heard the term ‘superfood’ before. In reality, despite its fancy name, ‘superfood’ is more often than not simply a marketing term used for foods that are exceptionally rich in nutrients. However, even amongst all ‘superfoods’, one in …

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5-Star Superfoods for your Gut!

Share on facebook Facebook Share on google Google+ Share on twitter Twitter Share on linkedin LinkedIn The bacteria in our gut can influence our mental health, weight, liver health, and blood sugar levels. When you nourish your gut microbiome with the right foods, you can change your health from the inside out. There are many …

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