Microbial influences in inflammatory bowel diseases

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Clinical, experimental, and therapeutic studies suggest an important role for microbial agents in Crohn’s disease and pouchitis pathogenesis. Bar-nich and Darfeuille-Michaud described adherent/invasive E. coli (AIEC) that persist within epithelial cells and macrophages and selectively colonize the ileum of Crohn’s disease patients.

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